Dr. Biplab Giri, Ph.D.

Assistant Professor

Department of Physiology
West Bengal State University,
Berunanpukuria, Malikapur,
Barasat, 24 Pgs (N), Kolkata- 700 126
West Bengal, INDIA
Mobile: 9432904884
E-mail: bgiri.cu@gmail.com

Academic Qualification:

1. Ph.D.: 2007, University of Calcutta
2. Post-Doc: Baylor College of Medicine, USA
   University of North Carolina, USA

• Dr. Biplab Giri earned his Masters and Ph.D. in Physiology from the University of Calcutta. During his Ph.D. he worked on “Molecular biology of cancer and alternative drug development against cancer” for which he was awarded “SEBM Young Scientist Mentee Award 2007” from USA. He also contributed multiple other projects on Osteoporosis, Pharmacology & Experimental Therapeutics of Venom & Toxins in the Department of Physiology, University of Calcutta. Following his Ph.D. he moved to Baylor College of Medicine, Houston, TX, USA to work first as Post Doctoral Research Fellow in a NIH research project on “Radiation induced oxidative stress in NQO1 & NQO2 knockout mice with special reference to leukemia & lymphoma”. After spending a significant effort in investigation on knockout mouse model, he moved to the School of Medicine, University of North Carolina, Chapel Hill, USA as Post Doctoral Research Associate to study the “Biology of stem cells & mechanisms determining differentiation of adult and embryonic stem cells with special emphasis on tissue regeneration” and also the “mechanisms that determine the ability of stem cell to regenerate following injury”. He joined the Department of Physiology, West Bengal State University, Kolkata in April 2009

• Currently, his research interest focuses on the molecular biology of cancer and cancer stem cell, better therapeutic drug development against cancer, osteoporosis, osteoarthritis and other degenerative diseases. The second focus of his laboratory is molecular mechanism of cancer stem cell plasticity, and lastly, stem cell differentiation, cell reprogramming and iPS cell research for the possible future therapy in degenerative diseases.

• “Experimental studies on the Interaction of Carbamate, Stress & Organophosphate”; DRDE, DRDO, Govt. of India (2010-2012).

1. Prof. Antony Gomes, Department of Physiology, University of Calcutta, Kolkata, India
2. Dr. Labanyamoy Kole, Syngene International Ltd., Bangalore, India
3. Prof. Adhip P.N. Majumder, Wayne State University, Michigan, USA

1. Post Doctoral Fellowship, NIH/NIHLB, USA sponsored research project (2007 to 2009).
2. ‘SEBM Young Scientist Mentee award’ for further research on the Doctorate thesis work in Wayne State University, USA. Awarded by the Society for Experimental Biology & Medicine, USA (Ref.: Experimental Biology & Medicine, June 2007)
3. D.N. Mallik award (Gold Medal) for first class first in M.Sc. Physiology, 2002 (Awarded by The Physiological Society of India).
4. First class ranked first in Master of Science degree, 2002 (University of Calcutta)

1. Life Member, Physiological Society of India (since 2004)
2. Life Member, Indian Pharmacological Society (since 2005)
3. Life Member, Indian Science Congress Association (since 2005)
4. Member, Indian Association for Cancer Research (since 2004)
5. Member, Society for Experimental Biology and Medicine (USA), since Jan. 2005
6. Member, International Society on Toxinology (UK), since Feb. 2006

Publications:

1. Anindita Debnath, Archita Saha, Antony Gomes, Sumit Biswas, Pinakpani Chakrabarti, Biplab Giri, Ajoy K Biswas, Shubho Das Gupta, Aparna Gomes. A lethal cardiotoxic-cytotoxic protein from the Indian monocellate cobra (Naja kaouthia) venom. Toxicon 2010; 56: 569-579 [Elsevier, UK]
2. Antony Gomes, Pushpak Bhattacharjee, Roshnara Mishra, Ajoy K Biswas, Subir C Dasgupta, Biplab Giri, Anindita Debnath, Subho Dasgupta, Tanaya Das, Aparna Gomes. Anticancer potential of animal venoms and toxins. Ind J Exp Biol 2010; 48: 93-103 [Review article]
3. Subhash Haldar, Shubho Dasgupta, Aparna Gomes, Biplab Giri, Subir Chandra Das Gupta, Ajay Biswas, Roshnara Mishra, Antony Gomes. A high molecular weight protein HBF1 from the Indian black Scorpion (Heterometrus bengalensis C.L.Koch) venom having anti osteoporosis activity in experimental animals. Toxicon 2010; 55(2-3): 455-61 [Elsevier, UK]
4. Biplab Giri, Antony Gomes, Radha Sengupta, Sanjeev Banerjee, Jyoti Nautiyal , Fazlul H. Sarkar, Adhip P. N. Majumdar. Curcumin Synergizes the Growth Inhibitory Properties of Indian Toad (Bufo melanostictus, Schneider) Skin Derived Factor (BM-ANF1) in HCT-116 Colon Cancer Cells. Anticancer Research 2009; 29(1): 395-401
5. Antony Gomes, Subhash Haldar, Biplab Giri, Roshnara Mishra, Archita Saha, Shubho Das Gupta, Aparna Gomes. Antiosteoporosis activity of the Indian black scorpion (Heterometrous bengalensis C.L.Koch) venom on experimental osteoporosis female albino rats. Toxicon 2009; 53(1): 60-68 [Elsevier, UK]
6. Antony Gomes, Biplab Giri, Labanyamoy Kole, Archita Saha, Anindita Debnath, Aparna Gomes. A crystalline compound (BM-ANF1) from the Indian toad (Bufo melanostictus, Schneider) skin extract, induced antiproliferation & apoptosis in leukemic & hepatoma cell line involving cell cycle proteins. Toxicon 2007; 50(6): 835-849 [Elsevier, UK]
7. Antony Gomes, S Roy Choudhury, Archita Saha, R Mishra, Biplab Giri, AK Biswas, Anindita Debnath, Aparna Gomes. A new protein toxin (drCT1) from Dabuia russellii venom having Antiproliferative and apoptogenic activity. Toxicon 2007; 49: 46-56 [Elsevier, UK]
8. Antony Gomes, Biplab Giri, Archita Saha, R Mishra, Subir C Dasgupta, A Debnath, Aparna Gomes. Bioactive molecules from amphibian skin: Their biological activities with reference to therapeutic potentials for possible drug development. Ind J Exp Biol 2007; 45(7): 579-593 [Review article]
9. S Dasgupta, A Debnath, A Saha, B Giri, G Tripathi, A Gomes, JR Vedasiromoni, A Gomes. Indian black scorpion (Heterometrus bengalensis, Koch) venom induced cytotoxic and apoptogenic activity against human leukemic U937 and K562 cells. Leukemia Research 2007; 31: 817-825 [Elsevier, USA]
10. B Giri, A Gomes, A Debnath, A Saha, A K Biswas, S C Dasgupta A Gomes, Antiproliferative, cytotoxic and apoptogenic activity of Indian toad (Bufo melanostictus, Schneider) skin extract in U937 & K562 cells. Toxicon 2006; 48(4): 388-400 [Elsevier, UK]
11. Archita Saha, Aparna Gomes, B Giri, A K Chakravarty, A K Biswas, S C Dasgupta and A. Gomes, Occurrence of non-protein low molecular weight cardiotoxin in the Indian King cobra (Ophiophagus hannah) venom. Ind J Exp Biol 2006; 44(4):279-285
12. A Saha, A Gomes, A K Chakravarty, A K Biswas, B Giri, S C Dasgupta and A Gomes, CNS and anticonvulsant activity of a non-protein toxin (KC-MMTx) isolated from King cobra (Ophiophagus hannah) venom. Toxicon 2006; 47(3):296-303 [Elsevier, UK]

Paper Presented in Conferences

1. Giri B & Gomes A, Antineoplastic activity of Indian common toad (Bufo melanostictus, Schneider) skin extract on EAC cell and human leukemic (HL60 & U937) cell line, in the 37th annual conference of Indian Pharmacological Society from 14th to 16th January 2005 held in Science City, Kolkata, India. (This Abstract published in the supplementary of Ind J Pharmacol, Vol 36, Dec.2004).
2. Biplab Giri, Labanyamoy Kole, Biochanin A, an isoflavone showed anti-proliferative and anti- inflammatory activities through the inhibition of iNOS expression, p38 phosphorylation and blocking NF_kB activation, in the International Conference on Integrative Physiology: Modern Perspective & Platinum Jubilee Celebration on the Physiological Society of India, held on Nov 12-14, 2009 at the Science City Convention Centre, Kolkata, India.
3. Biplab Giri and Antony Gomes, Antineoplastic molecule from the Indian toad (Bufo melanostictus, Schneider) skin extract, presented (oral) in International Conference on Frontier Research in Integrative Physiology (ICFRIP), held on Kolkata on 8th to 10th January, 2007.
4. Biplab Giri, Subir Chandra Dasgupta and Antony Gomes, Antioxidant and antineoplastic activity of Indian toad (Bufo melanostictus, Schneider) skin factor, presented (oral) in the Young Scientist Competitive session in the International conference on “Free Radicals and Antioxidants in Health, Disease and Radiation” held in Kolkata on 16th to 18th January 2006.
5. B Giri, S C Dasgupta and A Gomes, Antineoplastic factor(s) from Indian common toad (Bufo melanostictus, Schneider) Skin extract, in the International conference held on and from 25th to 26th February, 2005 at the Indian Institute of Chemical Biology (CSIR), Kolkata in collaboration with Jadavpur University, Kolkata & Drug Information Association (USA).