Chiranjib Pal.PhD

Assistant Professor ,

Department of Zoology,
West Bengal State University,
Berunanpukuria, Malikapur,
Barasat, 24 Pgs (N), Kolkata- 700 126
West Bengal, INDIA
E-mail: cpcu.immunology@gmail.com, Chiranjib.wbsu@gmail.com

Research Interest: Cellular Immunology & Experimental therapeutics

Leishmaniasis had taken an endemic form in 88 countries Africa, Asia, Europe, North America and South America with a total of 200 million people at risk with the new cases nearly 5, 00,000 per year. Dendritic Cells and Macrophages are the key factors in regulating the innate immune system and are centrally located in the host response against L. donovani infection. Production of reactive nitric oxide (NO) and cytokines like IL- 12 & IFN-gamma endows these cells and also potentates the T cells with potent antileishmanial activity. I am interested in -

1. Developing the immuno-prophylactic/ immuno-therapeutic strategies by cell / protein based agents against this deadly vector borne disease which has been included among the six major diseases for intensive research and control by World Health Organization (WHO).
2. Developing the herbal immunomodulators or novel chemotherapeutic strategies against experimental visceral leishmaniasis.
3. Status of myeloid (mDC) and plasmacytoid (pDC) Dendritic cells in experimental visceral leishmaniasis and active Kala-azar patient: its role in innate response.
4. Low cost generation of Dendritic Cells enhancing the T cell activation.

In Addenda, Formulation of low cost Immunonutrients / Nutraceuticals for the people below poverty line - the work on ancient knowledge in new package is going on in my laboratory.

Academic Qualification :

1. Postdoctoral Fellow- Department of Microbiology and Immunology H107, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA, 2004
2. Ph.D.- Department of Immunology & Infectious Diseases, Indian Institute of Chemical Biology, Jadavpur (Degree obtained from Jadavpur University), 2003
3. M.Sc. (Zoology) - University of Calcutta, 1994
4. B.Sc. (Zoology) - University of Calcutta, 1992

Fellowship-

1. National Scholarship, Ministry of Human Resource Development, Government of India.
2. Joint CSIR-UGC NET Examination and Eligibility for Lecturer.
3. Junior Research Fellow, Department of Biotechnology, Govt. of India.
4. Senior Research Fellow, Department of Biotechnology, Govt. of India.
5. Senior Research Fellow, Indian Council of Medical Research. Govt. of India.

Positions

Ongoing Project (s)

Patents & Publications--

1. A process for the Preperation of 2 Methyl-4-(Acetanilido)-Amino Quinoline, A novel Compound useful as an Antileishmanial Agent. Council of Scientific and Industrial Research, India, File No.-NF226/99).
2. A novel in vitro method to generate dendritic langerhans type cells using platelets. (USA Patent No. US 2002/0123140 A1. Assignee: Council of Scientific & Industrial Research, India).
3. Luteolin, an abundant dietary component is a potent Antileishmanial agent that acts by inducing topo II mediated Kinetoplast DNA cleavage leading to Apoptosis. Co-authored with B. Mitra, S. Bandyopadhyay & H K Majumdar - Molecular Medicine (2000), 6(6): 527-541. Impact Factor- 2.078 by 2007 Journal Citation Report. Publisher- The Feinstein Institute for Medical Research, USA.
4. Combination therapy with indolylquinoline derivative and sodium antimony gluconate cures established visceral leishmaniasis in hamsters. Co-authored with Santu Bandyopadhyay -Antimicrobial Agents and Chemotherapy (2002), 46(1): 259-261. Impact Factor- 4.379 by 2007 Journal Citation Report. Publisher- American Society of Microbiology.
5. Synthesis of 2-(2-methyl-quinolin-4-ylamino)-N-phenyl acetamide: a potential antileishmanial drug. Co-authored with Santu Bandyopadhyay - Bioorganic and Medicinal Chemistry (2002), 10:1687-1693.Impact Factor- 2.662 by 2007 Journal Citation Report. Publisher- Elsevier Science Ltd., USA.
6. Dendritic Cell-Based Immunotherapy Combined with Antimony-Based Chemotherapy Cures Established Murine Visceral Leishmaniasis. Co-authored with Monidipa Ghosh & Santu Bandyopadhyay - The Journal of Immunology, 2003, 170: 5625–5629 Impact Factor- 6.068 by 2007 Journal Citation Report. Publisher- The American Association of Immunologists.
7. Leishmania donovani infection of human myeloid dendritic cells leads to Th1 response in CD4+ T cells of normal donors and Kala-azar patients. Co-authored with M. Ghosh, L. Mandal & S. Bandyopadhyay - Journal of Infectious Diseases, (2006), 194(3): 294-301. (Impact Factor- 6.035 by 2007 Journal Citation Report. Publisher- Infectious Diseases Society of America.
8. Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report. Coauthored with U.C.Ghoshal & S.Bandyopadhyay - BMC Gastroenterology (2002), 2:6. Impact Factor- 1.98 by 2007 Journal Citation Report. Publisher- BioMed Central Ltd, London W1T 4LB, UK.
9. Dendritic Cells & Antigen Trapping Technology- A Revolution in Vaccine / Immunotherapy Strategy. Chiranjib Pal*, Indian Journal of Experimental Biology (2007), 45:491-504.* Corresponding Author.
10. S Mallick, S Maiti, AK Mandal, C Bandopadhyay C Pal* and B Saha* (2010). Differential leishmanicidal activity of methylchromone derivatives, approaching new molecules with less toxic effect. (Manuscript under preparation) *Joint corresponding Author.

Membership/ Ad-hoc Member

1. Ad-hoc Reviewer, Indian Journal of Experimental Biology, National Institute of Science Communication and Information Resources, CSIR, New Delhi.