Deba Prasad Mandal PhD

Lecturer ,

Department of Zoology,
West Bengal State University,
Berunanpukuria, Malikapur,
Barasat, 24 Pgs (N), Kolkata- 700 126
West Bengal, INDIA
E-mail: dpmandal1972@gmail.com

Research Interest :

I have been working in the field of tumor immunology and apoptosis. In future, primarily want to pursue research in the area of chemoprevention and toxicology. Interested in :

1. Identifying the therapeutic potential of various dietary agents/herbs (phytochemicals) along with elucidation of the possible biochemical and molecular pathways of action of the agents against developing tumor.
2. Identifying the immunomodulatory potential of various dietary agents/herbs in chronic diseases
3. Investigating the ecotoxicological impacts of pecticides, heavy metals and other environmental toxicants on the aquatic ecosystem.

Academic Qualification :

1. Ph.D.- Department of Animal Physiology, Bose Institute, Kolkata (Degree obtained from Jadavpur University), 2007
2. M.Sc. (Zoology) - University of Kalyani, 2001.

Performance in competitive exam

1. Qualified UGC-JRF (NET-July 2001); CSIR-JRF (NET-December 2001)
2. GATE (2001) [AIR – 301 Percentile- 84.36]

Fellowships-

1. Junior Research Fellowship, UGC-JRF, UGC India
2. Junior Research Fellowship, Council for Scientific and Industrial Research (CSIR), India

Positions

Patents & Publications-

1. Bhattacharyya A, Mandal D, Lahiry L, Sa G, Das T. Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett. 2004; 209:147-54.
2. Bhattacharyya A, Lahiry L, Mandal D, Sa G, Das T. Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int J Cancer. 2005; 117:308-15.
3. Mandal D, Bhattacharyya A, Lahiry L, Choudhuri T, Sa G and Das T. Failure in peripheral immunosurveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor bearer. Life Sci. 2005; 77: 2703-16.
4. Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi M, Sa G, Das T. Black tea protects thymocytes in tumor-bearing animals by differential regulation of intracellular ROS in tumor cells and thymocytes. J Environ Pathol Toxicol Oncol. 2005; 24:91- 104.
5. Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya S, Sa G, Das T.Tumor-induced thymic involution via Inhibition of IL-7Ra and its JAK-STAT signaling pathway: Protection by Black Tea. Int. Immunopharmacology. 2006; 6: 433-44.
6. Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G and Das T. Black teainduced decrease in IL-10 and TGF-b of tumor cells promotes Th1/Tc1 response in tumorbearer. Nutrition and Cancer. 2007, 58(2); 213-221.
7. Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S, Chattopadhyay S, Ghosh UK, Sa G, Das T. Black tea-induced amelioration of hepatic oxidative stress through antioxidative activity in EAC-bearing mice. J Environ Pathol Toxicol Oncol. 2007;26(4):245- 54.
8. Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T, Sa G. Curcumin prevents tumorinduced T-cell apoptosis through Stat-5a-mediated Bcl-2 induction. The Journal of Biological Chemistry. 2007; 282(22):15954-64.
9. Bhattacharyya S, Mandal D, Sen GS, Pal S, Benerjee S, Lahiry L, Finke JH, Tannenbaum, Sa G and Das T. Tumor-Induced Oxidative Stress Pertrubs Nuclear Factor –kB Activity-Augmenting Tumor Necrosis Factor-a-Mediated T-Cell Death: Protection by Curcumin. Cancer Research. 2007, 67: (1).
10. Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Banerjee S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G, Das T. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis. Apoptosis. 2008;13(6):771-81.

Book Chapter:

Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T. Cancer prevention by cancer regression and rejuvenation of host defense system: Dual role of tea. In: Medicinal Properties of Tea (Eds. B Banerjee & TC Chaudhury) Oxford & IBH Publishing Co. Pvt. Ltd., India, pp 89-112, 2005

Abstracts published in different international and national symposium.

1. Black tea as an immunological booster against immunosuppressive effects of Cancer and anti-cancer drugs. Deba Prasad Mandal, Arindam Bhattacharyya, Sreya Chattopadhay, Gaurisankar Sa and Tanya Das.
2. Monitoring host immune response vis-à-vis cancer development: A mechanistic Approach. Deba Prasad Mandal, Lakshmishri Lahiry, Arindam Bhattacharyya, Sreya Chattopadhay, Uttam Ghosh, Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and Tanya Das. Annual Meeting of Immunology Study Group- West Bengal and Current Trends in Immunology, Bose Institute, Kolkata, November 2002.
3. Role of black tea in countering tumor-induced thymic involution. Deba Prasad Mandal, Lakshmishri Lahiry, Arindam Bhattacharyya, Sreya Chattopadhay, Uttam Ghosh, Tathagata Choudhuri, Suman Pal, Gaurisankar Sa and Tanya Das. Annual Meeting of Immunology Study Group- West Bengal, CNCRI, Kolkata, September 2003.
4. Amelioration of tumor induced immunosuppression by black tea : A search for the mechanism. Deba Prasad Mandal, Lakshmishri Lahiry, Arindam Bhattacharyya, Uttam Ghosh and Tanya Das. National Seminar on Recent Advances in Stress Physiology, Toxicology and Immunology. University of Kalyani, November 2003.
5. Black tea prolongs the immune resistance against developing tumor countering the tumor-induced immunosupression. Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmishri Lahiry, Sankar Bhattacharyya, Uttam Ghosh, Gaurisankar Sa and Tanya Das.23rd Annual Convention of the Indian Association for Cancer Recearch. Special Symposium on Anti-Cancer Drug Development. ACTREC, Navi Mumbai, January 2004.
6. Black tea: Can it be a candidate for countering tumor-induced immunosuppression? Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmishri Lahiry, Sankar Bhattacharyya, Uttam Ghosh, Gaurisankar Sa and Tanya Das. Society of Biological Chemist (India) Kolkata Branch Seminar,Digha, May 2004.
7. Black tea: A double edged sword that induces tumor cell apoptosis and ameliorates immunosuppression of tumor-bearer. Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmishri Lahiry, Gaurisankar Sa and Tanya Das. International Symposium on Diet in Causation and Prevention of Cancer and XXX Annual Conference of Environmental Mutagen Society of India. ITRC, Lucknow, March 2005.
8. Black tea: Prevention of tumor induced thymic atrophy and amelioration of immunosuppression of tumor-bearer. Deba Prasad Mandal, Arindam Bhattacharyya, Lakshmishri Lahiry, Gaurisankar Sa and Tanya Das. International Symposium on Translational Research: Apoptosis and Cancer, Trivandrum, December, 2005