Dr. Sibani Chakraborty Ph.D

Lecturer ,

Department of Microbiology,
West Bengal State University,
Berunanpukuria, Malikapur,
Barasat, 24 Pgs (N), Kolkata- 700 126
West Bengal, INDIA
E-mail: sibani_chakraborty@yahoo.co.in

Dr. Chakraborty earned her Masters in Biochemistry from the University of Kalyani. She received her Ph.D degree from Jadavpur University while working at the Biophysics Department of Bose Institute, Kolkata under the direction of Prof. Asok Banerjee. During her Ph.D she received fellowship from Council of Scientific and Industrial Research, Govt. of India. Further she went for her post-doctoral training at the Department of Biochemistry & Molecular Biology, Brain Institute, University of Florida, Gainesville, USA and at the Crystallography & Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, India. Her research interests focused on the structural, biochemical and molecular elucidation of “interactions” that govern life processes. Models exploited includes both proteases and their inhibitors of the serine, cysteine and aspartic protease family with the ultimate goal of designing novel inhibitors that can be used as therapeutic agents for combating diseases.

List of Publications

1. Ghosh, R., Chakraborty, S., Chakrabarti, C., Dattagupta, J., K., and Biswas, S. (2008). Structural insight into the substrate specificity and activity of Ervatamins: the papain- like cysteine proteases from a tropical plant Ervatamia coronaria. FEBS Journal, 275, No.3, pp.421-434.
2. Moose, R., Clemente, J., Jackson, L., Ngo, M., Worten, K., Chang, R., Bennetle, A., Chakraborty, S., Yowell, C., Dame, J., Agbandje-Mckenna, M., Dunn, B (2007). Analysis of Binding Interactions of Pepsin Inhibitor-3 To Mammalian and Malarial Aspartic Proteases. Biochemistry, 46 (49), pp 14198-14205.
3. Sibani Chakraborty, Sampa Biswas, Chandana Chakrabarti and Jiban K. Dattagupta (2005). Crystallization and Preliminary X-ray diffraction studies of a cysteine protease Ervatamin A from Ervatamia coronaria. Acta Crystallographica, F61, 562-564.
4. Amrita Madabushi, Sibani Chakraborty, S. Zoe Fisher, Jose C. Clemente, Charles Yowell, John Dame, Ben Dunn, Mavis Agbandje-Mckenna & Robert Mckenna (2005). Crystallization and Preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae. Acta Crystallographica, F61, 228-231.
5. S.Chakraborty, A.K.Bera, S.Bhattacharya, S.Ghosh, A.K.Pal, Soumen.Ghosh and Asok Banerjee (2002). Synthesis ,microbiological study and X-ray structural characterization of a Tri-n-butylstannyl2-[4-(diethylamino)arylazo] benzene carboxylate. Journal of Organometallic Chemistry,USA. Vol. 645, 33-38.
6. S.Chakraborty, U. Haldar, A.K.Bera, A.K.Pal, S.Bhattacharya, S.Ghosh, B.P.Mukhopadhyay and Asok Banerjee (2001). Recognition and stabilisation of a unique CPRI-structural motif in Cucurbitaceae family Trypsin inhibitor peptides: Molecular dynamics based homology modeling using the X-ray structure of MCTI-II. Journal of Biomolecular Structure and Dynamics, USA. Vol. 18, Issue Number-4, 569-578
7. S.Chakraborty, U.Haldar, A.K.Bera, A.K.Pal, S.Bhattacharya, S.Ghosh, B. P. Mukhopadhyay and Asok Banerjee (2001). Hydrogen bonding potentiality of serine in more aquated environment: Crystal and molecular structure of dihydrated D-L Serine,C3H7NO3.2H2O. Indian Journal of Physics.Vol.75, PartA, no 5, 599-601.
8. S.Bhattacharya, A.K.Bera, S.Ghosh, S.Chakraborty, B.P.Mukhopadhyay, A.Pal and Asok Banerjee (2001). Regiospecificity of nucleotide-Amino acid mating Vs water dynamics: A key to Protein-Nucleic acid assemblies: Structure of unidecahydrated Inosine-5'-monophosphate and L-glutamic acid (2C10H13N4O3P.C5H11NO4.11H2O) cocrystal at atomic resolution.. Journal of Chemical Crystallography,USA Vol 30,no.10,655-663.
9. Asok K. Pal, S.Sen, S.Ghosh, A.K.Bera, S.Bhattacharya, S.Chakraborty and Asok Banerjee (2001). Research strategies for design and development of NSAIDs: clue to balance potency and toxicity of acetanilide compounds. Journal of Biomolecular Structure and Dynamics,USA. Vol. 19, Issue Number-1, 85-93.
10. Suparna Bhattacharya, S.Ghosh, S.Chakraborty, A.K.Bera, B.P. Mukhopadhyay I.Dey and Asok Banerjee (2001). Insight to subsite recognition in thiol protease-inhibitor complexes:Understanding specificity,the basis of differential inhibition.. BMC Structural Biology, 1:4, 345-352.
11. S.Chakraborty, S.Bhattacharya, S.Ghosh, A.K.Bera, A.K.Pal, U.C.Halder, B.P.Mukhopadhyay and Asok Banerjee (2000). Structural and interactional homology of clinically potential trypsin inhibitors: molecular modeling of Cucurbitaceae family peptides using X-ray structure of MCTI-II. Protein Engineering, Vol.13, no.8, 551-555.
12. Asok K. Pal, Sreya Ghosh, Asim K. Bera, Suparna Bhattacharya, Sibani Chakraborty, Kanai L.Ghatak and Asok Banerjee (2000). Structural basis of inactivation of thiol protease by N-acetyl-p-benzoquinone Imine (NAPQI). A knowledge based molecular modeling of the adduct of NAPQI with thiol protease of papain family. Journal of Molecular Modeling, Vol.6, 648-653.
13. A. Bera, B.P. Mukhopadhyay, S.Ghosh, S.Bhattacharya, S.Chakraborty and Asok Banerjee (1999). Influences of cooperative hydrogen bonding economy of protein-nucleic acid complexation: structure of unidecahydrated inosine C5’-monophosphate and L-glutamine (2C10H13N4O8P.C5H10N2O3.11H2O) cocrystal at atomic resolution. Journal of Chemical Crystallography,USA Vol.29, no.5, 531-540.
14. S. Ghosh, A. Bera, A. K. Pal, S. Bhattacharya, B. P. Mukhopadhyay, U. Halder, S. Chakraborty and Asok Banerjee (1999). The structural view of Nature’s another ‘Swiss Army Knife’, Calotropin DII, a thiol protease at 2.1Å resolution. Journal of Biosciences, vol.24, Supplement 1.